On almost perfect Saturday night, Ahoure beat into second place Jamaican superstar Veronica Campbell-Brown (10.83) to set the fastest time in the world this year.
In the preliminary rounds Ahoure had already clocked sizzling 10.80 seconds (Wind 2.1m/s).
The 28-year-old Ahoure broke the previous African record set by Blessing Okagbare in 2013 by 0.01 seconds.
American 17-year-old sprint sensation Candace hill took fifth place in the 100m final with a time of 11.19 seconds. She later returned to track win the 200m with a time of 22.38 seconds.
1 Ahoure`, Murielle Star Athletics/Nike 10.78
2 Campbell-Brown, Veronica 34 Modern Sprints 10.83
3 Atkins, Joanna 27 Life Speed 11.09
4 Whitney, Kaylin Star Athletics/Nike 11.17
5 Hill, Candace 17 Asics 11.19
6 White, Shelby 27 Hsinternational 11.21
7 Love, Alexis Star Athletics/Nike 11.33 11.330