Kilty will return to track after racing at last weekend's World Relays in Bahamas where British team finished in a disappointing 9th place.
Collins, who at age of 38 set his personal best and 2015 world indoors best mark of 6.47 seconds in February in Poland will contest after a 100m race in Guadalupe on Apri 2 where he was defeated by Asafa Powell.
Other top stars to compete in 100m in Manchester are British rising sprint star Chijindu Ujah, who went sub 10 for the first time last season, USA's Mike Rodgers the 2010 world indoor silver medalist and 'Flying Dutchman' Churandy Martina.
The meeting is expected to bring a crowd of 25,000 to Manchester city centre.
Other stars at Manhester Great City Gamea include Olympic heptathlon champion Jessica Ennis-Hill, Olympic long jump champion Greg Rutherford, European indoor pentathlon champion Katarina Johnson-Thompson, double world junior champion Morgan Lake, double European sprint champion Dafne Schippers of the Netherlands, and world champs medalist Tiffany Porter.
Great City Games Manchester will take place on Saturday May 9.